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  • Bubble point test
  • Diffusion (forward flow) test
  • Water intrusion test (for hydrophobic filters)
  • Correlation between integrity test values and microbial retention.

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Purchase Full Document: You can buy the PDF directly from the PDA Bookstore. The member price is approximately $180, while non-members pay $325. Bubble point test Diffusion (forward flow) test Water

The PDA Technical Report No. 26 (TR 26), titled "Sterilizing Filtration of Liquids," is widely regarded as the global gold standard for the selection, qualification, and validation of sterilizing-grade filters in pharmaceutical manufacturing. Originally published in 1998, it has undergone several revisions—most recently in November 2025—to reflect evolving regulatory expectations and advancements in filtration technology. Understanding PDA Technical Report 26