Juq-565 [2021] -

Introduction

Once I have a better understanding of your requirements, I'll do my best to assist you in crafting a well-written text! JUQ-565

Future research will also investigate hyper‑entanglement (simultaneous OAM and time‑bin entanglement) to further boost key rates, and distributed quantum repeaters compatible with high‑dimensional states, paving the way for continent‑scale quantum networks. Introduction Once I have a better understanding of

Abstract

JUQ‑565 is a recently discovered heterocyclic scaffold (C₁₈H₁₆N₄O₂) identified through a high‑throughput phenotypic screen targeting the phosphoinositide‑3‑kinase (PI3K)–Akt signaling axis in aggressive breast cancer models. Here we present a comprehensive pre‑clinical evaluation of JU‑565, covering synthetic route optimization, in‑vitro pharmacology, structure‑activity relationship (SAR) expansion, and in‑vivo efficacy in orthotopic xenograft models of triple‑negative breast cancer (TNBC). JUQ‑565 demonstrates sub‑nanomolar inhibition of PI3Kα (IC₅₀ = 0.42 nM) with >10,000‑fold selectivity over PI3Kβ/γ/δ, robust downstream Akt de‑phosphorylation, and potent antiproliferative activity (GI₅₀ = 8 nM) across a panel of TNBC cell lines. Pharmacokinetic profiling reveals high oral bioavailability (F = 62 %) and favorable tissue distribution, achieving therapeutic concentrations (> 10× IC₅₀) in tumor tissue for > 12 h after a single dose. In orthotopic mouse models, once‑daily oral dosing (30 mg kg⁻¹) resulted in a 78 % tumor growth inhibition (TGI) without overt toxicity. Mechanistic studies indicate that JUQ‑565 also sensitizes TNBC cells to DNA‑damage–inducing agents (e.g., carboplatin) through inhibition of Akt‑mediated DNA repair pathways. Together, these data position JUQ‑565 as a promising clinical candidate for PI3K‑driven malignancies, especially TNBC, and provide a blueprint for its further development. Cerf, N

Possible Contexts

  1. 1. Introduction

    The advent of large‑scale, fault‑tolerant quantum computers threatens the security of virtually all public‑key cryptographic schemes currently deployed on the Internet. While post‑quantum cryptography (PQC) offers a near‑term mitigation path, the only provably secure alternative is quantum‑key distribution (QKD), which exploits the no‑cloning theorem and the monogamy of entanglement to achieve information‑theoretic secrecy. Traditional QKD implementations—most notably BB84 and its variants—are limited by low key‑generation rates, stringent hardware requirements, and vulnerability to side‑channel attacks.

    Media/Video Identifiers: This alphanumeric format is often used for content IDs.

    References

    1. Cerf, N. J., Bourennane, M., Karlsson, A., & Gisin, N. (2002). Security of quantum key distribution using d‑level systems. Physical Review Letters, 88, 127902.
    2. Renner, R. (2005). Security of Quantum Key Distribution. Ph.D. thesis, ETH Zürich.
    3. Bos, J., Costello, D.,

    “I have a ship that remembers how to fly and a debt to settle,” Mara replied.