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2. Chemical and Pharmacological Foundations

| Aspect | Description | |--------|-------------| | Parent compound | Cocaine hydrochloride, a tropane alkaloid extracted from the leaves of Erythroxylum coca. | | Transformation into crack | Cocaine hydrochloride is mixed with a weak base (commonly baking soda, NaHCO₃) and water, then heated. The base converts the salt into a free‑base form that vaporizes at a much lower temperature, producing solid “rocks.” | | Route of administration | Smoked; the vapor is absorbed through the lungs, delivering the drug to the bloodstream within seconds. | | Pharmacodynamics | Acts primarily as a potent inhibitor of the dopamine transporter (DAT), as well as serotonin (SERT) and norepinephrine (NET) transporters. By blocking reuptake, it produces a massive surge of dopamine in the nucleus accumbens, the brain’s reward center. | | Onset & duration | Onset: 5–10 seconds after inhalation. Peak: 5–10 minutes. Duration of intense euphoria: 5–15 minutes, followed by a rapid “crash.” | | Metabolism | Primarily hepatic via esterases, yielding benzoylecgonine and ecgonine methyl ester, which are excreted in urine. | It seems like you're asking for information on

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